Synthesis, Characterization and Antimicrobial Activity of Novel Hydroxamic Acids of Pyrimidine 5-Carboxylic Acid and Their Complexes
Rashmi Tomar1, Bhawani Shankar2, Rakesh Kumar3, Madhu Godhara4, Vijay Kumar Sharma5
1Ms. Rashmi Tomar, Department of Chemistry, MSJ College, Bharatpur (Rajasthan), India.
2Mr. Bhawani Shankar, Department of Chemistry, Kirori Mal College, University, (Delhi), India.
3Dr. Rakesh Kumar, Department of Chemistry, Kirori Mal College, University, (Delhi), India.
4Dr. Madhu Godhara, Department of Chemistry, MSJ College, Bharatpur (Rajasthan), India.
5Dr. Vijay Kumar Sharma, Department of Physics, Shyam Lal College, University of Delhi, Delhi, India .
Manuscript received on 6 April 2014 | Revised Manuscript received on 17 April 2014 | Manuscript Published on 30 April 2014 | PP: 40-43 | Volume-3 Issue-11, April 2014 | Retrieval Number: K15850431114/14©BEIESP
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© The Authors. Blue Eyes Intelligence Engineering and Sciences Publication (BEIESP). This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Abstract: A series of metal complexes of Cu(II), Ni(II) and Co(II) have been synthesized with new hydroxamic acids, 1,3-dimethyl-2,4,6-trioxo-1,2,3,4,5,6-hexahydropyrimidine-5-car boxylic acid hydroxamide (5) and 1,3-dimethyl-4,6 -dioxo-2-thioxo-1,2,3,4,5,6-hexahydropyrimidine-5-carboxylic acid hydroxamide (6). During the course of present investigations, simple analytical and spectroscopic techniques such as repeated melting point (M.P.) determination, elemental analysis, running their thin layer chromatography for single spot, I.R., H1 -NMR and UV-Vis. (only for metal chelates) spectral studies were employed to indentify the purity and structure of hydroxamic acids and their metal chelates. Free ligands and their metal complexes have been screened for their antimicrobial activity against various species of fungi and bacteria.
Keywords: Hydroxamic Acids, Antimicrobial Activity, Metal Complexes.
Scope of the Article: Network Traffic Characterization and Measurements